Hypersense instruments

The “Hypersense Dynamic Nuclear Polariser instrument” was developed by Oxford Instruments in 2005. It is used to efficiently acquire data from nuclear magnetic resonance experiments in a laboratory setting. It is capable of amplifying the baseline sensitivity of NMR imaging’s signal to noise ratio by a factor of up to 10000 times, making NMR sensitive enough to be used for chemical structure confirmation and elucidation. The Hypsersense instrument beings the accuracy of NMR up to the level of some mass spectrometry methods. Its basic construction consists of a polarising superconducting magnet, dissolution or melting apparatus, and a microwave source. It is a modular unit and is compatible with most conventional NMR solvents, probes, and spectrometers. It is designed to be used by a single operator and automates data acquisition with little need for any manual intervention.

It is used in a wide array of fields where NMR is used in research, including metabolomic research into identifying biological markers to detect early stages of cancer, the characterization of compound libraries and identifying trace chemical species in the pharmaceutical industry, and in classical molecular chemistry research such as carbon nanotubes, fullerenes, pharmaceuticals containing nitrogen, and detecting silicon in biofluids reclaimed from implants.